OSTI.GOV Journal Article: Acute and subchronic toxicity of ethylene glycol monobutyl ether Title: Acute and subchronic toxicity of ethylene glycol monobutyl ether Full Record Acute toxicity values, such as oral and percutaneous LD 50 s, are often used as the basis for classifying chemicals into toxicity categories, and their subsequent regulation. It has many names including ethylene glycol monobutyl ether, ethylene glycol butyl ether, ethylene glycol n-butyl ether, Butyl Cellusolve, butyl glycol, and butyl Oxitol. The results of in vitro studies indicate that human red blood cells are not as sensitive as rat red blood cells to the haemolytic effects of 2-butoxyethanol and 2-butoxyacetic acid and also that red blood cells are more sensitive to haemolysis by 2-butoxyacetic acid than to haemolysis by 2-butoxyethanol. Furthermore, no treatment-related differences were found in body weight, organ weights, urine or serum chemistries, gross lesions, or microscopic lesions in males or females. Epub 2012 Jan 27. For butoxypropanol and BA, no OELs exist. Function and uses EGBE belongs to the group of glycol ethers, which are mainly used as solvents. The concentration dependence occurred at plausible in vivo doses. IRIS assessment development process. Fischer 344 rats exposed for 9 days (6 hr/day) over an 11-day period, to 0 (control), 19, 41, or 84 ppm EGHE had decreased body weight gains and increased liver to body weight values at 84 ppm EGHE. Mice were given various doses (62.5, 125, 250, 500, 1,000, 2,000 and 4,000 mg/kg body weight) of the compounds daily for 5 days/week, for 5 weeks. 2-Butoxyethanol is a clear colorless liquid that smells like ether. 2-Butoxyethanol Butyl cellosolve Dowanol EB Glycol butyl ether Poly-solv EB Call fire department. Dermal absorption may contribute substantially to the total uptake following skin contact with liquids or vapours containing EGME or EGMEA. Ethylene glycol poisoning is poisoning caused by drinking ethylene glycol. It is used as a solvent in spray lacquers, enamels, varnishes, and latex paints and as an ingredient in paint thinners and strippers, varnish removers, and herbicides. Exceptions do exist, such as the glomerular lesions in New Zealand Black (NZB) mice, which have been studied extensively, in a large number of animals, with sophisticated experimental laboratory techniques. Nearly all air concentrations [MEA (n = 68), glycol ethers (n = 79), BA (n = 15), and formaldehyde (n = 45)] were far below (<1/10) of the corresponding Swiss occupational exposure limits (OEL), except for ethylene glycol mono-n-butyl ether (EGBE). The available information on the acute and subchronic toxicity of ethylene glycol monobutyl ether is reviewed. For maternal rats at 79.2 ppm, there were transient decrease in body weight and body weight gain during exposure, reduced food consumption, increased water consumption, and excess lacrimation. The apparent Michaelis constant range from 0.32 to 0.70 mm while the maximum elimination rate ranged from 0.63 to 1.4 Î¼mol/min/g liver (parallel tube model) in six different experiments. This CICAD was approved as an international assessment at a meeting of the Final Review Board, held in Berlin, Germany, on 26-28 November 1997. COVID-19 is an emerging, rapidly evolving situation. Notify local health and pollution control agencies. In several studies, increased frequency of spontaneous abortions, disturbed menstrual cycle, and subfertility have been demonstrated in women working in the semiconductor industry. Please enable it to take advantage of the complete set of features! In the present study, the PFC response to TNP-LPS was used to evaluate the immunotoxic potential of ethylene glycol (EG) as well as the glycol ethers 2-methoxyethyl acetate (MEA), 2-(2-methoxyethoxy) ethanol, bis(2-methoxyethyl) ether, 2-ethoxyethanol and its principal metabolite 2-ethoxyacetic acid, 2-ethoxyethyl acetate, and 2-butoxyethanol relative to ME and MAA. Based upon the development of haemolytic effects in pregnant rats exposed during gestation, a sample tolerable concentration for humans of 13.1 mg 2-butoxyethanol/m3 has been derived. CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): The available information on the acute and subchronic toxicity of ethylene glycol monobutyl ether is reviewed. Bulletin of Environmental Contamination and Toxicology. | Effects on peripheral blood, testes, and sperm have been reported at occupational exposure levels ranging between 0.4 and 10 ppm EGME in air, and with additional, possibly substantial, dermal exposure. Based primarily on investigations in experimental animals, the critical health effects associated with exposure to 2-butoxyethanol are alterations in hematological parameters associated with hemolysis and lesions of the forestomach in mice. The purpose of this study was to determine the uptake, metabolism, and excretion of dermally administered glycol ethers as a function of the externally applied dose. Somade OT, Ajayi BO, Adeyi OE, Adeshina AA, James AS, Ayodele PF. eCollection 2020 Dec. Somade OT, Ajayi BO, Olushola MO, Omoseebi EO. Data from animal studies have been examined from the standpoint of dose-response relationships and the sensitivity of various animal species, including man, to the effects of this chemical. Similar, but less marked, hematologic effects were observed in rats exposed to 86 ppm of EGBE, while rats of the 20 ppm group were indistinguishable from controls. ETHYLENE GLYCOL N-BUTYL ETHER may react with bases, aluminum and oxidizing materials. Washington, DC All propylene glycol ethers are currently believed to be relatively safe; most ethylene glycol ethers with "methyl" in their names are relatively toxic. In an acute inhalation study on Wistar albino rats, a 4-hr exposure to 83 ppm EGHE produced no clinical signs, body weight effects, mortality, or macroscopic lesions in thoracic or abdominal organs. Access scientific knowledge from anywhere. Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data, as outlined in the . Increased absolute and/or relative liver weights were observed in both sexes of the 71-ppm group and to a lesser extent in the 41-ppm group. The effects of ethylene glycol alkyl ethers on testis and embryotoxic effects of ethylene glycol monomethyl ether (EGM) have been studied, as has the teratogenicity of ethylene glycol dimethyl ether (EGdM). Appl. Owing to the short half-life of 2-butoxyethanol in the atmosphere, measured or predicted concentrations of this chemical in air are considered to have no environmental significance. Environ Health Perspect. The major urinary metabolite was 2-(2-butoxyethoxy)acetic acid. No evidence was found for excretion of 2-butoxyacetic acid, which has been shown to exert haematological effects in rats. In animals, adverse effects on reproduction and development have not been observed at less than toxic doses. EGME and EGMEA are efficiently absorbed by inhalation as well as via dermal penetration. Urine was collected for 24 h and analyzed for the metabolite butoxyacetic acid, also by gas chromatography. In the 2-week studies, groups of five male and five female rats and mice received 2-methoxyethanol, 2-ethoxyethanol, or 2-butoxyethanol in the drinking water. 2019 Oct-Dec;10(4):184-189. doi: 10.4103/japtr.JAPTR_57_19. General Formula. Notable observations included loss of coordination, red stained urine, and enlarged discolored kidneys at 867 and 523 ppm. 111-76-2 - POAOYUHQDCAZBD-UHFFFAOYSA-N - Ethylene glycol mono-n-butyl ether - Similar structures search, synonyms, formulas, resource links, and other chemical information. Many lesions have been described only in morphologic terms and without good clinical histories and laboratory work-ups. Methyl cellosolve-induced renal oxidative stress and time-dependent up-regulation of pro-inflammatory cytokines, apoptotic, and oncogenic markers in rats. MicroRNA profiles in a monkey testicular injury model induced by testicular hyperthermia. The dermal LDÃ¢Ã¢ value was found to be between 2 and 4 g/kg. At the conclusion of the 90-day exposure regimen, the hematologic effects seen in the females had lessened (RBC was 7% below control) or returned to control value ranges. Ethylene Glycol 107-21-1 Hazard Summary Ethylene glycol has many uses, including as antifreeze in cooling and heating systems, in hydraulic brake fluids, and as a solvent. 2016 Dec;36(12):1614-1621. doi: 10.1002/jat.3326. U.S. Environmental Protection Agency . 90-118. Based on limited data from case reports and one laboratory study, similar acute effects - including haemolytic effects as well as effects on the central nervous system - are observed in humans and rats exposed to 2-butoxyethanol, although the effects are observed at much higher exposure concentrations in humans than in rats. Data from animal studies have been examined from the standpoint of dose-response relationships and the sensitivity of various animal species, including man, to the effects of this chemical. Stability No data submitted 3.2. Dermally administered glycol ethers were metabolized differently than glycol ethers administered in drinking water (M. A. Medinsky, G. Singh, W. E. Bechtold, J. There were no significant biological effects in rats exposed subchronically to 25 or 5 ppm. The elimination kinetics of 2-butoxyethanol (ethylene glycol monobutyl ether, EGBE) were studied in the once-through isolated perfused rat liver system in the presence and absence of ethanol. Abstract. Toxic doses being expressed as mg/kg body weight, esterification seemed to weaken the atrophic action of EGM and EGE, but when expressed as mol/kg, significant difference was found neither between EGM and EGMA nor between EGE and EGEA. EPA has denied a petition to remove Ethylene Glycol Monobutyl Ether (EGBE) from the list of chemicals subject to reporting under section 313 of the Emergency Planning and Community Right-to-Know Act (EPCRA). Ethylene Glycol: The general formula for ethylene glycol is C 2 H 6 O 2. 2005 Mar 28;156(1):13-28. doi: 10.1016/j.toxlet.2003.08.010. Glycol ethers should be handled with all the care that should be taken in the safe use of organic solvents. Ethylene glycol monobutyl ether (EGBE) (2-Butoxyethanol); CASRN 111-76-2. In evaluating the hazard that this chemical may pose to man, consideration has been given to likely routes of exposure and its irritant properties. Fundam Appl. (NTP, 1992). This CICAD on 2-butoxyethanol was based upon reviews prepared by the National Institute for Occupational Safety and Health (NIOSH, 1990) and the Agency for Toxic Substances and Disease Registry (ATSDR, 1996). Reproductive toxicity of the glycol ethers. Although only detected once, EGBE air concentrations (n = 4) were high (49.48-58.72mg m(-3)), and close to the Swiss OEL (49mg m(-3)). The contribution of EGME in relation to other exposure factors in the semiconductor industry is unclear. Gestational parameters monitored were numbers of corpora lutea, preimplantation losses, viable implants, early and late resorptions, and dead fetuses. Monitors for maternal toxicity were body weight, food and water consumption, clinical signs, and hematology. Although the results of in vitro tests for mutagenicity of 2-butoxyethanol were inconsistent, the absence of structural alerts and the negative findings from in vivo studies are sufficiently reassuring to allow the conclusion that 2- butoxyethanol is not mutagenic. Slight, but statistically significant, decreases in RBC (13% below control) and Hgb, accompanied by an increase in MCH (11% above control) were observed in the 77 ppm-exposed females after 6 weeks. | Urogenital wetness was observed in all EGHE-exposed groups of females and in males of the 71-ppm group. Possibly related to these findings in the liver were decreases in serum transaminases (aspartate and alanine aminotransferase) and sorbitol dehydrogenase, with an increase in alkaline phosphatase observed in the 71-ppm group of female rats. Effects of single vapor exposure of EGBE to laboratory animals. HHS Data from animal studies have been examined from the standpoint of dose-response relationships and the sensitivity of various animal species, including man, to the effects of this chemical. Decreased body weight gains were observed in both sexes of the 71-ppm group, and a slight decrease was also observed in females of the 41-ppm group. Sakurai K, Mikamoto K, Shirai M, Iguchi T, Ito K, Takasaki W, Mori K. J Appl Toxicol. Transient eye irritation and barely perceptible skin irritation were among, We tried out the potential irritant and sensitizing effect of the main glycol ethers found in industrial and consumer products. In a subsequent study, rats were exposed for 9 days (6 hr/day) to EGBE concentrations of 245, 86, 20, or 0 (control) ppm. This colorless liquid has a sweet, ether-like odor, as it derives from the family of glycol ethers, and is a butyl ether of ethylene glycol. On admission the 53-year-old patient was comatose with metabolic acidosis, shock, and noncardiogenic pulmonary edema confirmed by haemodynamic study. Bond, P. J. Sabourin, L. S. Birnbaum, and R. F. Henderson, 1990, Toxicol. ETHYLENE GLYCOL MONOBUTYL ETHER (EGBE) (CAS No. Acute (short-term) exposure of humans to ethylene glycol by ingesting large quantities causes three stages of health effects: central nervous system (CNS) depression, followed by Toxicities of ethylene glycol (EG) and 6 ethylene glycol mono alkyl ethers administered orally were studied. Based upon limited data, ambient exposures in air are generally in the Î¼g/m3 range. Three different amounts of the Â¹â´C-labeled glycol ethers (450â4000 Î¼mole/kg) were applied to same-sized areas on the clipped backs of rats, and nonoccluded percutaneous absorption was measured. The signal transduction of xanthone as a protector on 2-methoxyethanol-induced cardiac cell damage in mice. Within the dose range studied, the absorption and metabolism of these three glycol ethers by rats was linearly related to the dermally applied dose. The estimated half-life of 2-butoxyethanol in water is approximately 1-4 weeks, and the chemical is likely readily biodegraded in aerobic soil and water. Feces and exhaled CO2 represented minor routes of excretion. Integrated Risk Information System (IRIS) March 2010 . Data from animal studies have been examined from the standpoint of dose-response relationships and the sensitivity of various animal species, including man, to the effects of this chemical. 2020 Aug 17;7:100051. doi: 10.1016/j.metop.2020.100051. Exposure of rodents to high concentrations of BE resulted in anemia due to hemolysis of blood cells, leukopenia, hemoglobinuria, and liver and kidney damage. 2-Butoxyethanol (BE) is a massively produced glycol ether of which more than 230 million pounds was produced in the United States in 1983. Sections I (Health Hazard Assessments for Noncarcinogenic Effects) and Embryonic deaths in monkeys and impaired spermatogenesis in rabbits have been reported after daily oral doses of 12 and 25 mg per kg body weight, respectively. It is a colourless liquid that is miscible in water and soluble in most organic solvents. Cutaneous irritation was determined in the rabbit following the EEC method (European Economic Communities) and the Draize protocol, and the sensitizing effect was evaluated in the guinea pig by the maximized Magnusson and Kligman method. Would you like email updates of new search results? 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